Most adverse effects have been mild and transient and have rarely required the withdrawal of therapy Cardiovascular, bradycardia, congestive heart failure, intensification of AV block; hypotension, paresthesia of hands: thrombocytopenic purpura, arterial insufficiency, usually of the Central Nervous System lightheadedness; mental depression manifested by insomnia, lassitude, weakness, fatigue, reversible mental depression progressing to catatonia, visual disturbances, action hallucinations; an acute reversible syndrome characterized by disorientation for time and place, short-term memory loss, emotional lability, slightly clouded sensonum, and Gastrointestinal nausea, vomiting, epigastric distress, abdominal cramping, diarrhea, constipation, mesenteric arterial thrombosis, ischemic colitis Allergic pharyngitis and agranulocytosis, erythematous rash, fever combined with aching and sore throat, laryngospasm and respiratory distress Hematologic: agranulocytosis, nonthrombocytopenic purpura, thrombocytopenic Auto-Immune In extremely rare instances, systemic lupus erythematosus has been involving the skin, serous membranes and conjunctivae reported for a beta blocker (practolol) have not been associated with propranolol DOSAGE AND ADMINISTRATION.
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